Simulation of Laser Ablation

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About Mimesis and LaserOptimal teams

The Mimesis team focuses on the use of real-time simulation for per-operative guidance. The underlying objectives include numerical techniques for real-time computation and data-driven simulation dedicated to patient-specific modeling. In the field of tumor ablation, the Mimesis is jointly working with the LaserOptimal team at Politecnico Milano.

Funded by an ERC grant, the LaserOptimal team works in Milano on the control of the energy delivery in tumors, aiming to minimize the unwanted heat dispersion into the surrounding healthy tissue. The multidisciplinary team is working on the design of a patient-specific platform, useful to plan the treatment and to monitor the laser ablation evolution in real-time, in conjunction with the injection of nanoparticles, used to enhance the selectivity of the treatment.

Clinical context

In the last decades, innovative technologies in the field of interventional radiology rose to meet the requirements of minimally invasive procedures. Thus, a wide range of thermal ablation techniques is now available for tumor ablation. Radio-frequency (RF) ablation was the most common technique, however, it can cause adverse events such as stroke (due to blood clot formation). Alternative techniques have therefore been developed such as laser, microwave, HIFU, cryoablation. All these techniques aim at generating a lesion within the tumor by heating or freezing the cells, until irreversible thermal damage to the cells.

In this project, we will focus on laser ablation. The laser approach demonstrated low tumor recurrence after ablation, which is the most severe drawback of RF and cryoablation. The use of fiber optics to deliver the energy into the target makes possible the use of Computed Tomography and Magnetic Resonance images for both the guidance and the monitoring of the treatment (no artifact on images). Fiber optics are small and flexible, allowing the combined use with flexible endoscopy and limiting the tissue trauma when inserted into the organs.

A key to the success of all ablation techniques is the definition of the laser settings leading the treatment of the entire tumor, while avoiding critical damage to the surrounding tissues.
Until now, the therapy planning mostly depends on the clinician’s experience. Commercial systems for planning are nearly non existent. Besides, the prediction must account for the influence of the soft tissue properties or the presence of blood vessels.

Skills

  • Knowledge in thermodynamics, FEM and numerical methods would be great, a plus would be knowledge in optimization methods
  • Knowledge in C++, python
  • Most of all, motivation is needed!

Job information

  • Job location: Politecnico Milano, several travers are planned to MIMESIS team in Strasbourg, in the Nouvel Hopital Campus (France).
    Contract: 1 up to 2 years
  • Start: ASAP
  • Salary: starting from 1460€ depending on experience

Application

You have a PhD: apply here!

Without PhD: apply here!

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